Research Development Committee

Kappa Delta Award/OREF Clinical Research Award: Past Winners




1950 Winner(s)

Researcher(s): Dr Marshall R. Urist and Colleagues

Project: The Mechanism of Endosteal Bone Formation in Estrogen Treated Mice

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1951 Winner(s)

Researcher(s): Dr Vernon P. Thompson and Dr Vernon D. Epstein

Project: Traumatic Dislocation of the Hip, A Survey of 204 Cases Covering a Period of Twenty-One Years

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1952 Winner(s)

Researcher(s): Dr Robert A. Robinson

Project: An Electron Microscopic Study of the Crystalline Inorganic Component of Bone and its Relationship to the Organic Matrix

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1953 Winner(s)

Researcher(s): Dr Charles F. Gregory and Dr George J. Garceau

Project: Bone Healing by Vital Staining Methods

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1954 Winner(s)

Researcher(s): Dr Robert D. Ray

Project: The Development of Experimental Techniques and Their Application to Studies of Bone Growth and Metabolism

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1955 Winner(s)

Researcher(s): Dr Charles W. Goff

Project: The Legg-Calve-Perthes Syndrome

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1956 Winner(s)

Researcher(s): Dr Ignacio V. Ponseti

Project: Lesions of the Skeleton and Other Mesodermal Tissues which might be due to Aminoitrile Intake

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1957 Winner(s)

Researcher(s): Dr Leonard F. Peltier

Project: An Appraisal of the Problem of Fat Embolism

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1958 Winner(s)

Researcher(s): Dr W.F. Enneking

Project: The Effect of Total Body Irradiation on Bone Transplants in Parabiosed Animals

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1959 Winner(s)

Researcher(s): Dr Melvin J. Glimcher

Project: Molecular Structure and Biological Specificity in Mineralization

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1960 Winner(s)

Researcher(s): Dr William S. Smith

Project: A Correlated Clinical and Experimental Approach to the Etiology of Congenital Dislocation of the Hip

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1961 Winner(s)

Researcher(s): Dr Kirk J. Anderson

Project: Experimental Investigations of Large and Small Fragment Bone Implants and Extracts of Heterogenous Bone

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1962 Winner(s)

Researcher(s): Dr Robert C. Mellors

Project: Rheumatoid Arthritis and the Cellular Origin of Rheumatiod Factors

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1963 Winner(s)

Researcher(s): Dr Mary S. Sherman and Dr Roshen Irani

Project: The Pathologic Anatomy of the Clubfoot


Researcher(s): Dr J. William Fielding

Project: Cineradiography


Researcher(s): Dr Paul H. Curtis, Jr, and Dr LeRoy Klein

Project: Possible Mechanisms of Articular Cartilage Destruction in Septic Arthritis

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1964 Winner(s)

Researcher(s): Dr George W.N. Eggers

Project: Cystic Change in the Iliac Acetabulum


Researcher(s): Dr William F. Neuman, PhD

Project: The Current Status of the Mechanisms of Calcification

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1965 Winner(s)

Researcher(s): Dr Jerome Gross

Project: Mechanism of Connective Tissue Remodeling


Researcher(s): Dr O. Donald Chrisman

Project: Biochemical Aspects of Osteoarthritis


Researcher(s): Dr Richard S. Riggins and Dr Yosef H. Pilch

Project: Studies of the Antigenicity of Fibrosarcoma

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1966 Winner(s)

Researcher(s): Dr Carl E. Anderson

Project: Invasion and Resorption in Enchondral Ossification: An Electron Microscopic Study

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1967 Winner(s)

Researcher(s): Dr Gerald A.M. Finerman and Dr Leon E. Rosenberg

Project: Regulation of Amino Acid Transport and Collagen Synthesis in Fetal Rat Bone


Researcher(s): Dr Robert L. Fisher and Dr Frances DeGeorge, MA

Project: Idiopathic Scoliosis: An Investigation of Genetic and Environmental Factors

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1968 Winner(s)

Researcher(s): Dr James M. Burkhart

Project: Parathyroid and Thyroid Hormones in the Development of Immobilizaation Osteoporosis


Researcher(s): Dr G.V.B. Cochran

Project: Electromechanical Characteristics of Moist Bone


Researcher(s): Dr Wayne H. Akeson

Project: Experimental Arthroplasty of the Canine Hip: Extra cellular Matrix Composition in Non-Interpositional Arthroplasty and Cup Arthroplasty

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1969 Winner(s)

Researcher(s): Dr Sandy C. Marks, Jr, DDS., PhD

Project: The Parafollicular Cell of the Tyroid Gland as the Source of a Potent Osteoblast-Stimulating Factor. Evidence from Experimentally Osteopetrotic Mice


Researcher(s): Dr Walter Abendschein and Dr George W. Hyatt

Project: Ultrasonics and Selected Physical Properties of Bone


Researcher(s): Dr J. Robert Close

Project: The Functions of the Muscles of the Thumb, the Middle and Index Fingers

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1970 Winner(s)

Researcher(s): Dr William H. Harris and Dr Robert H. Heaney

Project: Growth Hormone: The Effect on Skeletal Renewal in the Adult Dog


Researcher(s): Dr Lawrence C. Rosenberg

Project: Chemical Basis for the Histolig Use of Safranin O in the Study of Articular Cartilage


Researcher(s): Dr Jorge Galante, Dr William Rostoker, PhD, Dr Roger Lueck, and Dr Robert D. Ray, PhD

Project: Sintered Fiber Metal Composites as a Basis for Attachment of Implants to Bone

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1971 Winner(s)

Researcher(s): Dr Clive C. Solomons, PhD, Dr Edward A. Milar, Dr William E. Hathaway, and Dr John E. Ott

Project: Osteogenesis Imperfecta: New Perspectives in Diagnosis and Treatment


Researcher(s): Dr. Reginald R. Cooper

Project: Skeletal Muscle Alterations During Immobilization, Denervation, Regeneration and Embryonic Myogenesis


Researcher(s): Dr Joseph M. Lane, Dr Darwin J. Prockop, Dr Peter Dehm, PhD, and Dr Lincoln J. Parkes, DVM

Project: Inhibition of Collagen Synthesis in Chick Embryos by the Proline Analogue L-Azetidine-2-Carboxylic Acid

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1972 Winner(s)

Researcher(s): Dr Burton W. Marsh, Dr Leo Flynn, and Dr William F. Enneking

Project: Immunologic Aspects of Osteosarcoma


Researcher(s): Dr Adrian E. Flatt

Project: Problems in the Treatment of Ulnar Drift


Researcher(s): Dr B. Lawrence Riggs

Project: Bone Turnover--Sex Hormone--Parathyroid Hormone Relationships in Post-Menopausal Osteoporosis

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1973 Winner(s)

Researcher(s): Dr Eric L. Radin, Dr Igor L. Paul, SCD, and Dr Robert M. Rose, ScD

Project: Studies of Joint Function


Researcher(s): Dr F. Richard Convery, Dr Donald R. Gunn, FRCS, Dr J. David Hughes, and Dr Wayne E. Martin

Project: The Systemic Manifestations of Polymethyl Methacrylate


Researcher(s): Dr Stephen M. Krane, Dr Sheldon R. Pinnell, and Dr Richard W. Erbe

Project: Collagen Lysyl Hydroxylase Deficiency: A New Heritable Disorder of Connective Tissue

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1974 Winner(s)

Researcher(s): Dr Carl T. Brighton

Project: Significance of Tissue Oxygen Tension, Glycolysis and Mitochondrial Calcium Release in Epiphyseal Plate Calcification


Researcher(s): Dr Edward D. Harris, Jr, and Dr Peter A. McCroskery, MS

Project: Degradation of Human Cartilage Collagen Fibrils by Rheumatoid Synovial Collagenase


Researcher(s): Dr. Frederic W. Rhinelander

Project: Circulation in Bone

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1975 Winner(s)

Researcher(s): Dr David S. Howell, PhD, Dr David Simon, PhD, and Dr Julio C. Pita, PhD

Project: Role of Extracellular Matrix Vesicles in InitialCalcification of Healing Rachitic Cartilage


Researcher(s): Dr Jennifer Jowsey, PhD

Project: Morphological Studies of the Etiology and Treatment of Osteoporosis


Researcher(s): Dr Henry J. Mankin

Project: Metabolism of Articular Cartilage in Health and Disease

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1976 Winner(s)

Researcher(s): Dr William H. Harris

Project: Post-Operative Thromboembolic Disease: The Results of a Concerted Attack on a Complex Problem


Researcher(s): Dr Augusto Sarmiento and Dr Loren Latta, P. Eng

Project: Factors Controlling the Behavior of Tibial Shaft Fractures--A Correlation of Laboratory and Clinical Studies


Researcher(s): Dr Augustus A. White, III, Dr Manohar M. Panjabi, PhD, Dr Edmund S. Crelin, PhD, and Dr Wayne O. Southwick

Project: A Quantitative Biomechanical Study of Fracture Repair

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1977 Winner(s)

Researcher(s): Dr Frank R. Noyes and Dr Edward S. Grood, PhD

Project: Functional Properties of Knee Ligaments and Alterations Induced by Immobilization


Researcher(s): Dr Jacquelin Perry and Dr M. Mark Hoffer

Project: Pre and Post-Operative Studies of Muscle Activity in the Cerebral Palsied Child Using Dynamic Electromyography as an Aid in Planning Tendon Transfers


Researcher(s): Dr Aaron S. Posner, PhD

Project: The Relation of Synthetic Amorphus Calcium Phosphate to Bone Mineral Structure

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1978 Winner(s)

Researcher(s): Dr Klaus E. Kuettner, PhD

Project: The Resistance of Cartilage to Normal and Neoplastic Invasion


Researcher(s): Dr. Robert W. Bright

Project: Surgical Correction of Partial Growth Plate Closure--Experience with 52 Children


Researcher(s): Dr John E. Kenzora, Dr Robert E. Steele, and Dr Zvi H. Yosipovitch

Project: Experimental Osteonecrosis of the Femoral Head in Adult Rabbits

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1979 Winner(s)

Researcher(s): Dr Adele L. Boskey, PhD

Project: Calcium Acidic Phospholipid Phosphate Complexes in Tissue Mineralization


Researcher(s): Dr William T. Green, Jr

Project: Articular Cartilage Repair: Investigation by the Cell Culture of Isolated Chonodrocytes


Researcher(s): Dr A. Seth Greenwald, PhD, and Dr Mary-Blair Matejczyk

Project: Comparative Mechanics of the Hip and Ankle

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1980 Winner(s)

Researcher(s): Dr Thomas E. Whitesides, Jr, Dr Hiroshi Harada, and Dr Kazuo Morimoto

Project: Compartment Syndromes and the Role of Fasciotomy, its Parameters and Techniques


Researcher(s): Dr James A. Rand

Project: A Comparison of Open Intramedullary Nailing and Compression Plate Fixation on Fracture Site Blood Flow and Fracture Union

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1981 Winner(s)

Researcher(s): Dr Van C. Mow, PhD, and Dr Cecil G. Armstrong, PhD

Project: Variations in the Intrinsic Mechanical Properties of Human Articular Cartilage with Age, Degeneration and Water Content


Researcher(s): Dr Marshall R. Urist

Project: New Bone Formation Induced in Post-Fetal Life by Bone Morphogenetic Protein"


Researcher(s): Dr Theodore R. Oegema, Jr, PhD

Project: Proteoglycan Synthesis and Structure in Human and Rabbit Nucleus Pulposis: A Possible Relationship to Function


Researcher(s): Dr Wilson C. Hayes, PhD

Project: Stress-Morphology Relationships in Trabecular Bone of the Patella

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1982 Winner(s)

Researcher(s): Dr H. Clark Anderson

Project: Matrix Vesicle Calcification


Researcher(s): Dr Gary E. Friedlaender

Project: Apropos Bone Allografts


Researcher(s): Dr Alfred B. Swanson

Project: Bone Remodeling Phenomena in Flexible (Silicone) Implant Arthroplasty in the Hand--Long Term Study


Researcher(s): Dr Richard A. Brand, Dr Roy D. Crowninshield, PhD, and Richard C. Johnston

Project: Muscle and Joint Force Predictions and Their Uses

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1983 Winner(s)

Researcher(s): Dr Savio L-Y Woo, PhD

Project: Internal Fixation Plates for Fracture Management-New Design Concepts


Researcher(s): Dr William J. Landis, PhD

Project: Studies of Mineralizing Tissues Using Anhydrous Techniques for Electron Optical and Microprobe Analysis


Researcher(s): Dr Robert H. Fitzgerald, Jr

Project: The Pharmacokinetics of Antibiotics in Normal and Osteomyelitic Bone


Researcher(s): Dr Thomas P. Andriacchi, PhD

Project: Interaction Between Knee Joint Mechanics and Patient Function Following Total Knee Replacement

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1984 Winner(s)

Researcher(s): Dr Michael G. Ehrlich

Project: Degradative Enzyme Systems in Cartilage


Researcher(s): Dr Raymond T. Morrissy and Dr Darrel W. Haynes, PhD

Project: Acute Hematogenous Osteomyelitis: A Model with Trauma as an Etiologic Agent


Researcher(s): Dr Kai-Nan An, Ph.D., Dr. Edmund Y.S. Chao, Ph.D., Dr. William P. Cooney, III, and Dr. Ronald L. Lincheid

Project: Biomechanics of the Hand--A Basic Research Study


Researcher(s): Dr R. William Petty

Project: Influence of Skeletal Implant Materials on Infection

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1985 Winner(s)

Researcher(s): Dr Richard H. Gelberman and Dr Paul R. Manske

Project: Flexor Tendon Repair


Researcher(s): Dr Clinton T. Rubin, PhD

Project: The Osteoregulatory Nature of Mechanical Stimuli


Researcher(s): Dr Christopher H. Evans, PhD

Project: Ferrographic and Biochemical Studies on the Wear Particles of Human and Prosthetic Joints


Researcher(s): Dr Victor M. Goldberg, Dr E. Power, Dr John W. Shaver, Dr Jaclyn M. Zika, PhD, Dr Gary Bos, and Dr Kingsbury G. Heiple

Project: Bone Grafting: The Barrier to Transplantation

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1986 Winner(s)

Researcher(s): Dr Bruce Heppenstall, Dr Alexander Sapega, and Dr Bruce Chance, PhD

Project: Intracellular Energy Metabolism During Ischemia and Skeletal Muscle under Various Clinical Conditions with Articular Reference to 31P-NMR Spectroscopy as a New Investigative Diagnostic Technique


Researcher(s): Dr Andrew J. Weiland

Project: Fate of Vascularized Bone Grafts


Researcher(s): Dr Edith R. Schwartz, PhD

Project: Phosphorylation of Proteoglycans and Link Proteins in Human Articular Cartilage


Researcher(s): Dr William F. Blair, Dr Thomas D. Brown, PhD, and Dr E.R. Greene, PhD

Project: Pulsed Ultrasound Doppler Velocimetry in the Assessment of Microvascular Hemodynamics

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1987 Winner(s)

Researcher(s): Dr Alan R. Hargens, PhD, Dr Wayne H. Akeson, and Dr Scott J. Mubarak

Project: Tissue Fluid Pressures: From Basic Research Tools to Clinical Application


Researcher(s): Dr. Steven P. Arnoczky, DVM

Project: The Meniscus: Its Repair and Replacement


Researcher(s): Dr Robert B. Salter

Project: The Biological Concept of Continuous Passive Motion of Synovial Joints: The First 16 Years of Basic Research and its Clinical Application


Researcher(s): Dr Jane B. Lian, PhD

Project: Osteocalcin: Properties, Synthesis, and Role in Bone Resorption

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1988 Winner(s)

Researcher(s): Dr David L. Butler, PhD

Project: The Anterior Cruciate Ligament: Its Normal Response and Replacement Institution


Researcher(s): Dr Steven L. Teitelbaum

Project: The Cellular Mechanisms of Bone Resorption


Researcher(s): Dr Peter Grigg, PhD and Dr Allen H. Hoffman, PhD

Project: Neuronal Mechanoreceptors as a Probe for Tissue Mechanics

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1989 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Timothy M. Wright, PhD, Donald L. Bartel, PhD, and Clare M. Rimnac, PhD

Project: Surface Damage in Polyethylene Total Joint Components


Elizabeth Winston Lanier Award

Researcher(s): Anthony R. Poole, PhD, Carolyn Webber, MSC, Henry J. Mankin, MD, Subhash Pal, PhD, and Lawrence C. Rosenberg, MD

Project: Protoglycans of Human Chondrosarcomas: Immunoanalysis Using Monoclonal Antibodies to Keratan Sulfate and A Fetal-Associated Epitope


Young Investigator Award

Researcher(s): Stephen B. Tripple, MD

Project: Growth Factor Regulation of Cartilage

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1990 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Ernesto Canalis, MD

Project: The Role of Insulin-Like Growth Factor in the Local Regulation of Bone Remodeling


Elizabeth Winston Lanier Award

Researcher(s): Arnold I. Caplan, PhD

Project: Mesenchymal Stem Cells


Young Investigator Award

Researcher(s): Steven A. Goldstein, PhD, and Larry S. Matthews, MD

Project: The Mechanical, Morphologic, Architectural and Remodeling Characteristics of Trabecular Bone

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1991 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Stanley J. Bigos, MD

Project: A Longitudinal Prospective Study of Industrial Back Injury Reporting


Elizabeth Winston Lanier Award

Researcher(s): A.H. Reddi, PhD

Project: Purification, Cloning and Expression of Osteogenin, A Protein Initiator of Bone Differentiation


Young Investigator Award

Researcher(s): W.P. Andrew Lee, MD

Project: Toward Clinical Realization of Vascularized Limb Tissue Allografts

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1992 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Linda J. Sandell, PhD

Project: Expression of Collagen and Aggrecan Genes During Skeletal Development and Growth: Control at Transcription and Post-transcription


Elizabeth Winston Lanier Award

Researcher(s): Louis V. Avioli, MD

Project: A New Post Receptor Signalling Pathway for Parathyroid Hormone in the Osteoblast


Young Investigator Award

Researcher(s): Sharon Stevenson, DVM, PhD

Project: Critical Biological Determinants of Cortical Bone Allograft Incorporation: Quantifying a Complex Process and Structure

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1993 Winner(s)

Ann Doner Vaughn Award

Researcher(s): J. Grodzinsky, ScD


Elizabeth Winston Lanier Award

Researcher(s): Gary S. Stein, PhD, and Jane B. Lian, PhD

Project: Molecular Mechanisms Regulating Osteoblast Growth and Differentiation


Young Investigator Award

Researcher(s): D. Rick Sumner, PhD, Thomas M. Turner,MD, Robert M. Urban, MD and Jorge O. Galante, MD

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1994 Winner(s)

Ann Doner Vaughn Award

Researcher(s): James R. Urbaniak, MD, Anthony V. Seaber, and Long-En Chen, PhD

Project: Blood No Reflow in Skeletal Muscle After Replantation


Elizabeth Winston Lanier Award

Researcher(s): Robert J. Johnson, MD, Bruce D. Boynon, PhD, Braden C. Fleming, MS, Claude E. Nichols, MD, Per A. Renstrom, MD, PhD, Malcolm H. Pope, MD, SC, PhD, and James G. Howe, MD

Project: The Biomechanics of the Anterior Cruciate Ligament and Bone-Patella Tendon-Bone Graft in Vivo


Young Investigator Award

Researcher(s): Richard L. Lieber, PhD, and Jan Friden, MD, PhD

Project: Mechanism and Prevention of Skeletal Muscle Injury

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1995 Winner(s)

Ann Doner Vaughn Award

Researcher(s): John M. Cavanaugh, MS, A. Cuneyt Ozataktay, MD, Toshihiko Yamahita, MD, Avram Avramov, MD, Thomas V. Getchell, PhD, and Albert I. King, PhD

Project: Mechanisms of Low Back Pain: A Neurophysiological and Neuroanatomical Study


Elizabeth Winston Lanier Award

Researcher(s): Randy N. Rosier, Regis J. O'Keefe, David G. Hicks, Paul R. Reynolds, and J. Edward Puzas

Project: Autocrine Regulation of Cartilage


Young Investigator Award

Researcher(s): Stephen P. Horowitz, MD

Project: The Biology of Aseptic Loosening of the Cemented Arthroplasty: An In-Vitro Study

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1996 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Malcolm H. Pope, PhD, Marianne Magnusson, and David G. Wilder, PhD

Project: Low Back Pain and Whole Body Vibration


Elizabeth Winston Lanier Award

Researcher(s): Kathryn G. Vogel, Stephen P. Evanko, and James R. Robbins, MD

Project: What Proteoglycan Content Says About the Medical History of Tendon


Young Investigator Award

Researcher(s): Jon J.P. Warner, MD, Richard E. Debski, and Freddie H. Fu, MD

Project: A Dynamic Model for Motion and Stability of the Glenohumeral Joint


OREF Clinical Research Award

Researcher(s): Dale M. Daniel, Donald C. Fithian, Mary Lou Stone, Barbara E. Dobson, William F. Luetzow, MD, and Kenton R. Kaufman

Project: A Ten-Year Prospective Outcome Study of the ACL-Injured Patient

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1997 Winner(s)

Ann Doner Vaughn Award

Researcher(s): William E. Garrett, MD, Anthony V. Seaber, Thomas M. Best, Richard R. Glisson, Pantelis K. Nikolaou, MD, and Dean C. Taylor, MD

Project: Muscle Strain Injury: Basic Science and Clinical Application


Elizabeth Winston Lanier Award

Researcher(s): James N. Weinstein, DO, MS, Kevin F. Spratt, G.F. Gebhart, Mamoru Kawakami, MD, Stephen T. Meller, Nobuhior Hayashi, Hwanmo Lee, and Ken-Inchi Chatani

Project: Lumbar Radiculopathy: An Animal Model with Relevance to Clinical Practice


Young Investigator Award

Researcher(s): Denis R. Clohisy, MD

Project: Cellular Mecahnisms of Tumor Osteolysis


OREF Clinical Research Award

Researcher(s): Dale M. Daniel, Marc F. Swiontkowski, MD, Diane Martin, Ruth Engelberg, and Julie Agel

Project: The Development and Validation of a Musculoskeletal Extremity Health Status Instrument: The Musculoskeletal Functional Assessment Instrument

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1998 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Henry A. McKellop, PhD

Project: Development of an Extremely Wear Resistant Ultra High Molecular Weight Polyethylene for Total Hip Replacements


Elizabeth Winston Lanier Award

Researcher(s): Bruce Caterson, PhD

Project: The Use of Monoclonal Antibody Technology to Study Cartilage in Health and Disease: A Retrospective and Historical Review


Young Investigator Award

Researcher(s): Farshid Guilak, PhD

Project: The Biomechanics of the Chondrocyte in Articular Cartilage


OREF Clinical Research Award

Researcher(s): Stuart L. Weinstein, MD

Project: Natural History and Long Term Outcomes of Treatment of Pediatric Orthopaedic Conditions

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1999 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Julia Bridge

Project: A Genetic Approach to Bone and Soft Tissue Tumors


Elizabeth Winston Lanier Award

Researcher(s): Thomas Einhorn, MD

Project: A Model of Experimental Fracture Healing for Basic and Applied Research


Young Investigator Award

Researcher(s): Scott Boden, MD

Project: The Biology of Lumbar Spine Fusion and the Use of Bone Graft Substitutes: Present, Future, and Next Generation...


OREF Clinical Research Award

Researcher(s): Andrew L. Koman, MD, Thomas L. Smith, Zhongyu Li, Beth Paterson Smith

Project: Peripheral Microvascular Control Mechanisms

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2000 Winner(s)

Ann Doner Vaughn Award

Researcher(s): L.E. Dahners, MD, and G.E. Lester, PhD

Project: On Changes in Length of Dense Collagenous Tissue: Growth and Contracture


Elizabeth Winston Lanier Award

Researcher(s): R. Tracy Ballock, MD

Project: Regulation of Endochondral Ossification by Thyroid Hormone


Young Investigator Award

Researcher(s): Qian Chen, PhD

Project: Molecular Regulation of Chondrocyte Differentiation


OREF Clinical Research Award

Researcher(s): Benjamin A. Alman, MD, and Jay S. Wunder, MD

Project: Developmental Pathways in Musculoskeletal Neoplasia: Aggressive Fibromatosis and the Wingless (Wnt) Pathway

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2001 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Scott P. Bruder, MD, PhD

Project: Bone Generation and Regeneration: From Embryonic Chicks to Human Clinical Therapy


Elizabeth Winston Lanier Award

Researcher(s): Myron Spector, PhD

Project: Expression of Muscle Action in Contraction of Chondrocytes, Osteoblasts, and Musculoskeletal Tissue Fibroblasts


Young Investigator Award

Researcher(s): Robert L. Sah, MD, ScD

Project: Articular Cartilage Tissue Engineering: Biological and Biomechanical Foundations


OREF Clinical Research Award

Researcher(s): Bruce J. Sangeorzan, MD, Allan Tencer, PhD, and Randy Ching, PhD

Project: Changes in the Talo-Calcaneal Joint in Pathological Conditions in the Hindfoot

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2002 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Joshua J. Jacobs, MD; Anastasia K. Skipor, MD; Robert M. Urban; Nadim J. Hallab, PhD; Leslie Pattern, RN; and Jonathan Black, PhD

Project: Systemic Implications of Total Joint Replacement


Elizabeth Winston Lanier Award

Researcher(s): James G. Wright, MD; Gillian A. Hawker, MD; and Peter C. Coyte, PhD

Project: Area Variation and Unmet Need for Orthopaedic Surgical Procedures


Young Investigator Award

Researcher(s): Yousef Abu-Amer, PhD

Project: Regulation of Inflammatory Bone Loss Diseases: Unveiling Molecular Targets for Therapeutic Intervention


OREF Clinical Research Award

Researcher(s): Joseph D. Zuckerman, MD; and Kenneth J. Koval, MD

Project: Hip Fractures in the Elderly: A Comprehensive Clinical and Research Approach

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2003 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Michael J. Bosse, MD; Ellen J. MacKenzie, PhD; James F. Kellam, MD; Andrew R. Burgess, MD; Lawrence Webb, MD; Marc F. Swiontkowski, MD; Roy Sanders, MD; Alan L. Jones, MD; Mark P. McAndrew, MD; Brendan M. Patterson, MD; Melissa McCarthy, ScD; Thomas G. Travison, PhD; Renan C. Castillo, MS

Project: Limb Salvage or Amputation Following Severe Lower Extremity Trauma: The LEAP Study


Elizabeth Winston Lanier Award

Researcher(s): Clinton T. Rubin, PhD

Project: Revisiting Wolff's Law: The Physiologic Basis and Anabolic Potential of Low Magnitude, High Frequency Mechanical Signals


Young Investigator Award

Researcher(s): Edward M. Greenfield, PhD; Yanming Bi, PhD; Ashraf A. Ragab, MD; Victor M. Goldberg, MD; Jennifer L. Nalepka, BS; Joscelyn M. Seabold, MS

Project: Does Endotoxin Contribute to Aseptic Loosening?


OREF Clinical Research Award

Researcher(s): John J. Callaghan, MD; Douglas R. Pedersen, PhD; Richard C. Johnston, MD; Thomas D. Brown, PhD

Project: The Clinical Biomechanics of Wear in Total Hip Arthroplasty

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2004 Winner(s)

Ann Doner Vaughn Award

Researcher(s): Brian D. Snyder, MD, PhD; John A. Hipp, PhD; Ara Nazarian, MSc

Project: Non-Invasive Prediction of Fracture Risk Due to Benign and Metastatic Skeletal Defects


Elizabeth Winston Lanier Award

Researcher(s): Joseph S. Torg, MD; Helene Pavlov, MD; Albert Burstein, PhD

Project: The Pathomechanics, Pathophysiology, and Prevention of Reversible and Irreversible Cervical Spinal Cord Injury: Results of a Thirty-Year Clinical Experience


Young Investigator Award

Researcher(s): Johnny Huard, PhD

Project: Gene Therapy and Tissue Engineering Based on Muscle-Derived Stem Cells: Potential for Musculoskeletal Tissue Regeneration and Repair


OREF Clinical Research Award

Researcher(s): Frank R. Noyes, MD; Edward Grood, PhD; Thomas Andriacchi, PhD; Sue Barber-Westin, BS

Project: Factors Affecting the Treatment of Anterior Cruciate Ligament-Deficient Knees with Lower Limb Malalignment and Associated Ligamentous Instabilities: A Correlated, Clinical, Biomechanical, and Dynamic Gait Analysis

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2005 Winner(s)

Young Investigator Award

Researcher(s): Edward M. Schwarz, PhD

Project: Utility of Recombinant Adeno-Associated Virus Vectors for Orthopaedic Gene Therapy


Elizabeth Winston Lanier Award

Researcher(s): Darryl D. D'Lima, MD; Martin K. Lotz, MD; Clifford Colwell, Jr., MD

Project: Cartilage Injury Chondrocyte Apoptosis and Matrix Degradation: In Vitro, In Vivo, and Clinical Consequences


Ann Doner Vaughn Award

Researcher(s): Paul D. Robbins, PhD; Steven C. Ghivizzani, PhD

Project: Gene Delivery Approaches to the Treatment of Orthopaedic Disorders


OREF Clinical Research Award

Researcher(s): Mininder S. Kocher, MD, MPH; David Zurakowski, PhD; James R. Kasser, MD

Project: Septic Arthritis of the Hip in Children: An Evidenced-Based Approach to Improving Clinical Effectiveness

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2006 Winner(s)

Young Investigator Award

Researcher(s): Ranjan Gupta, MD

Project: Schwann Cell Regulation of Chronic Nerve Injury


Elizabeth Winston Lanier Award

Researcher(s): Kristy Weber, MD, Michele Doucet, MS, Scott Kominsky, PhD

Project: Growth Factor Receptor Signaling Blockade in Renal Cell Carcinoma Bone Metastasis


Ann Doner Vaughn Award

Researcher(s): Tong-Chuan, He, MD, PhD, Rex C. Haydon, MD, PhD

Project: The Distinct Roles of Bone Morphogenetic Proteins in Mesenchymal Stem Cell Differentiation


OREF Clinical Research Award

Researcher(s): Kevin J. Bozic, MD, MBA, Patricia Katz, PhD, Jonathan Showstack, PhD, James Naessens, MPH, Harry E. Rubash, MD, Michael D. Ries, MD, Daniel J. Berry, MD

Project: Using Clinical and Economic Outcome Data to Influence Health Policy in the United States: The Case of Total Joint Replacement

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2007 Winner(s)

Young Investigator Award

Researcher(s): Constance R. Chu, MD

Project: Integrating Bench to Operating Room: Journey of a Clinician-Scientist


Elizabeth Winston Lanier Award

Researcher(s): Martha L. Gray, PhD, Deborah Burstein, PhD, Young-Jo Kim MD, PhD, Alice Maroudas, PhD

Project: Magnetic Resonance Imaging of Cartilage Glycosaminoglycan: Basic Principles, Imaging Technique, and Clinical Applications


Ann Doner Vaughn Award

Researcher(s): David L. Butler, PhD, Natalia Juncosa- Melvin, Ph.D, Gregory P. Boivin, D.V.M., Marc T. Galloway, M.D., Jason T. Shearn, Ph.D., Cynthia Gooch, B.S., Hani Awad, Ph.D.

Project: Functional Tissue Engineering for Tendon Repair: A Multidisciplinary Strategy using Mesenchymal Stem Cells, Bioscaffolds and Mechanical Stimulation


OREF Clinical Research Award

Researcher(s): Christian Gerber, MD, FRCSEd(hon)

Project: Rotator Cuff Disease: From Scientific Understanding to Patient Care

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2008 Winner(s)

Young Investigator Award

Researcher(s): Chuan-ju Liu, PhD; Yi Luan, MD, PhD; Yan Zhang, MD, PhD; Ronald Damani Howell, BS; and Li Kong, MD

Project: ADAMTS-7 and ADAMTS-12: Two Novel Cartilage-Degrading Metalloproteinases


Elizabeth Winston Lanier Award

Researcher(s): Michele C. Battié, PhD; Tapio Videman, MD, PhD; Jaakko Kaprio, MD, PhD; Laura E. Gibbons, PhD; Kevin Gill, MD; Janna Saarela, MD, PhD; and Leena Peltonen, MD, PhD

Project: The Foundation of a New Paradigm of Disc Degeneration: The Twin Spine Study


Ann Doner Vaughn Award

Researcher(s): Karen M. Lyons, PhD and Vicki Rosen, PhD

Project: In Vivo Studies of BMP Pathway Activities in Chondrogenesis


OREF Clinical Research Award

Researcher(s): Hans-Christoph Pape, MD

Project: Effects of Changing Strategies of Fracture Fixation on Immunologic Changes and Systemic Complications After Multiple Trauma: Damage Control Orthopaedic Surgery

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2009 Winner(s)

Young Investigator Award

Researcher(s): Stavros Thomopoulos, PhD

Project: Structure, Biomechanics, and Mechanobiology in the Attachment of Tendon to Bone


Elizabeth Winston Lanier Award

Researcher(s): Michael J. Yaszemski, MD, PhD and Lichun Lu, PhD

Project: Osteoinductive Injectable Degradable Polymeric Scaffolds for Osseous Defect Repair


Ann Doner Vaughn Award

Researcher(s): Hiroshi Kawaguchi, MD, PhD, Toru Akune, MD, PhD, Takashi Yamada, MD, PhD and Naoshi Ogata, MD, PhD

Project: Mouse Genetics Studies on Molecular Mechanisms Underlying Bone and Cartilage Disorders


OREF Clinical Research Award

Researcher(s): Lawrence C. Hurst, MD, Marie A. Badalamente, PhD and Edward D. Wang, MD

Project: Injectable Clostridial Collagenase: Striving Toward Nonoperative Treatment Options for Fibroproliferative Disorders

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2010 Winner(s)

Young Investigator Award

Researcher(s): Brian K. Kwon, MD, PhD, FRCSC

Project: Cerebrospinal Fluid Pressure Monitoring and Biochemical Analysis in Acute Spinal Cord Injury - A Translational Approach


Elizabeth Winston Lanier Award

Researcher(s): Cornelia E. Farnum, DVM, PhD
Co-Author: Norman J. Wilsman, DVM, PhD

Project: Analyzing the Growth Plate in Four Dimensions - A Thirty-year Perspective on Growth Plate Dynamics


Ann Doner Vaughn Award

Researcher(s): Louis J. Soslowsky, PhD

Project: Understanding the Etiology, Pathogenesis, and Repair Response of Rotator Cuff Injuries: A Series of Interconnected Studies Developing and Using an Animal Model


OREF Clinical Research Award

Researcher(s): Mohit Bhandari, MD
Co-Authors: Gordon Guyatt, Stephen Walter, Emil Schemitsch, Dave Sanders, Marc Swiontkowski, and Paul Tornetta, III

Project: Setting a New Benchmark for Collaborative Trials in Trauma: The Rationale, Design, and Execution of the Study to Prospectively Evaluate Intramedullary Nails in Tibial Shaft Fractures (S.P.R.I.N.T.)

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2011 Winner(s)

Young Investigator Award

Researcher(s): Young-Min Kwon, MD, PhD, FRCS, FRACS

Project: Evidence-Based Approach in Understanding 'Pseudotumour' in Metal-on-Metal Hip Replacements


Elizabeth Winston Lanier Award

Researcher(s): Howard S. An, MD
Co-Authors: Koichi Masuda, MD; Gabriella Cs‐Szabo, PhD; Yejia Zhang, MD, PhD; Ana Chee, PhD; Gunnar B.J. Andersson, MD, PhD; Hee-Jeong Im, PhD; Eugene J-M.A. Thonar, PhD

Project: Intervertebral Disc Repair or Regeneration by Growth Factor and/or Cytokine Inhibitor Protein Injection


Ann Doner Vaughan Award

Researcher(s): Bang H. Hoang, MD
Co-Authors: Yi Guo, MD; Randall F. Holcombe, MD; Xiaolin Zi, MD

Project: Project: Toward Novel Therapeutic Intervention for Osteosarcoma: Clinical Implications of the WNT Pathway


OREF Clinical Research Award

Researcher(s): Donald D. Anderson, PhD
Co-Authors: J. Lawrence Marsh, MD; Thomas D. Brown, PhD

Project: The Pathomechanical Etiology of Post-traumatic Osteoarthritis Following Intra-articular Fractures

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2012 Winner(s)

Young Investigator Award
Researcher(s): Xudong Joshua Li, MD, PhD

Project: GDF5 Modulation in Intervertebral Disc Degeneration


Elizabeth Winston Lanier Award
Researcher(s): Jay R. Lieberman, MD

Project: Regional Gene Therapy to Enhance Bone Repair


Ann Doner Vaughan Award
Researcher(s): Kurt P. Spindler, MD
Co-Authors: Richard D. Parker, MD, Jack T. Andrish, MD, Christopher C. Kaeding, MD, Rick W. Wright, MD, Robert G. Marx, MD, MSc, Eric C. McCarty, MD, Annunziato Amendola, MD, Warren R. Dunn, MD, MPH, Laura J. Huston, MS, Frank E. Harrell, Jr., PhD

Project: Prognosis and Predictors of ACL Reconstructions using the MOON Cohort: A Model for Comparative Effectiveness Studies


OREF Clinical Research Award
Researcher(s): Thomas D. Brown, PhD
Co-Authors: Jacob M. Elkins, MS, Douglas R. Pedersen, PhD, John J. Callaghan, MD

Project: Impingement and Dislocation in Total Hip Arthroplasty: Mechanisms and Consequences

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2013 Winner(s)

Young Investigator Award
Researcher(s): Elise F. Morgan, PhD

Project: Control of Bone Healing by Mechanical Factors


Elizabeth Winston Lanier Award
Researcher(s): Richard L. Lieber, PhD
Co-Authors: Samuel R. Ward, PT, PhD, Jan Friden, MD, PhD

Project: Design of Human Skeletal Muscles: Implications For Orthopaedic Surgery
More on the winners


Ann Doner Vaughan Award
Researcher(s): Martha M. Murray, MD
Co-Author: Braden C. Fleming, PhD

Project: The Biology of ACL Injury and Repair


OREF Clinical Research Award
Researcher(s): Robert F. LaPrade, Md, PhD
Co-Authors: Steinar Johansen, MD, Lars Engebretsen, MD, PhD, Chad J, Griffith, MD / Benjamin R. Coobs, MD, Andrew G. Geeslin, MD

Project: Improving Outcomes for Posterolateral Knee Injuries Running Title: The Posterolateral Corner of the Knee

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2014 Winner(s)

Young Investigator Award
Researcher(s): Brian Feeley, MD

Project: Understanding the development of muscle atrophy and fatty infiltration in massive rotator cuff tears


Elizabeth Winston Lanier Award
Researcher(s): Freddie H. Fu, MD

Project: Anatomic Anterior Cruciate Ligament Reconstruction: A Changing Paradigm


Ann Doner Vaughan Award
Researcher(s): Ken Yamaguchi, MD, MBA
Co-Authors: Sharlene A. Teefey, MD, Jay D. Keener, MD, Leesa Galatz, MD

Project: Natural History of Rotator Cuff Disease: Relationship to Surgical Indications


OREF Clinical Research Award
Researcher(s): James N. Weinstein, MD, MS
Co-Authors: Adam M. Pearson, MD, MS, Jon D. Lurie, MD, MS, Tor D. Tosteson, ScD, Anna N.A. Tosteson, ScD, William A. Abdu, MD, MS, Sohail K. Mirza, MD, MPH

Project: The Spine Patient Outcomes Research Trial (SPORT)

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2015 Winner(s)

Young Investigator Award
Researcher(s): Robert L. Mauck, PhD
Co-Authors: Dawn M. Elliott, PhD and Jason A. Burdick, PhD

Project: Engineering Dense Connective Tissues: Mechanical, Material, and Mechanobiologic Considerations

Ann Doner Vaughn Award
Researcher(s): Steven A. Olson, MD
Co-Authors: Farshid Guilak, PhD, Virginia Kraus, MD, PhD, Bridgette Furman, BS, and Janet Huebner, MS

Project: Early Inhibition of Proinflammatory Cytokines Prevents Post-Traumatic Arthritis: Insights from the Natural History of Arthritis Developing after Intra-Articular Fracture
More on the winners

Elizabeth Winston Lanier Award
Researcher(s): William D. Bugbee, MD
Co-Authors: Andrea L. Pallante-Kichura, PhD, Simon Görtz, MD, Robert Sah, MD, ScD, and David Amiel,

Project: Osteochondral Allograft Transplantation in Cartilage Repair: Graft Storage Paradigm, Translational Models, and Clinical Applications
More on the winners

OREF Clinical Research Award
Researcher(s): Stuart L. Weinstein, MD
Co-Authors: Lori A. Dolan, PhD

Project: The Evidence Base for the Prognosis and Treatment of Adolescent Idiopathic Scoliosis

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2016 Winner(s)

Young Investigator Award
Researcher:Louis DeFrate, ScD

Project: The effects of ACL graft placement on in vivo knee function and cartilage thickness distributions

Ann Doner Vaughn Award
Researcher: Francis Lee, MD, PhD

Project: Targeting Innate Immune Inflammatory Pathways in Osteolytic Disorders: Unmasking the Two Faces of Osteoprogenitor Cells

Elizabeth Winston Lanier Award
Researcher: Edward Wojtys, MD
Co-Author: James A. Ashton-Miller, PhD

Project: On Knee Function and ACL Injury

OREF Clinical Research Award
Researcher: Timothy Hewett, PhD
Co-Authors: Gregory D. Myer, PhD; Kevin R. Ford, PhD; Mark Paterno, PhD; Carmen Quatman, MD, PhD

Project: Mechanisms and Prevention of ACL Injuries: Cutting ACL Injury Risk with Finely Sharpened Tools

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2017 Winners

2017 Kappa Delta Young Investigator Award

Researcher: Robin Queen, PhD, FACSM

Project: Using Lower Extremity Biomechanics in Patients with Ankle Osteoarthritis and Ankle Arthroplasty to Direct Clinical Care


2017 Kappa Delta Ann Doner Vaughn Award

Researcher: Matthew Dobbs, MD  

Co-Author: Christina Gurnett, MD, PhD

Project: Advancing Mrecision Medicine for Clubfoot Treatment through Basic Research


2017 Kappa Delta Elizabeth Winston Lanier Award

Researcher: Scott W. Wolfe, MD

Co-Author: Joseph J. Crisco, III, PhD

Project: Kinematics of the Normal and Injured Wrist: The Importance of the Midcarpal Joint


2017 OREF Clinical Research Award 

Researcher: Henrik Malchau, MD, PhD  

Co-Authors: Göran Garellick, MD, PhD; Daniel Berry, MD; William H. Harris, MD, ScD  

Project: Arthroplasty Implant Registries Over The Past Five Decades: Development, Current and Future Impact

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2018 Winners

2018 Kappa Delta Young Investigator Award

Researcher: Nelly Andarawis-Puri, PhD

Co-Author: Evan L. Flatow, MD

Project: Promoting Effective Tendon Healing and Remodeling


2018 Kappa Delta Ann Doner Vaughn Award

Researcher: Johnny Huard, PhD

Project: Adult Stem Cells, Blood Vessels, and Angiogenesis: Major Determinants for Musculoskeletal Tissue Repair After Injury, Disease, and Aging


2018 Kappa Delta Elizabeth Winston Lanier Award

Researcher: Paul E. Beaulé, MD, FRCSC

Co-Authors: George Grammatopoulos, MD, FRCS, PhD; Andrew Speirs, PhD; Geoffrey Ng, PhD; Sasha Carsen, MD; Hanspeter Frei, PhD; Gerd Melkus, PhD; Kawan Rakhra, MD; Mario Lamontagne, PhD

Project: Unravelling the Hip Pistol Grip / CAM Deformity: Origins to Joint Degeneration


2018 OREF Clinical Research Award

Researcher: Gregory B. Maletis, MD

Co-Authors: Tadashi T. Funahashi, MD; Maria C.S. Inacio, PhD; Liz Paxton, MA

Project: Optimizing Anterior Cruciate Ligament Reconstruction: Individualizing the Decision Making Process Using Data from the Kaiser Permanente ACLR Registry

2019 Winners 

2019 Kappa Delta Young Investigator Award

Researchers: Sherry Liu, PhD

Co-Authors: Chantal M. de Bakker, PhD and Yihan Li, MS

Project: Understanding Functional Adaptation of Maternal Bone to Reproduction and Lactation


2019 Kappa Delta Ann Doner Vaughn Award

Researchers: Rick Wright, MD

Co-Authors:  Amanda K. Haas, MA, Christina R. Allen, MD, Daniel E. Cooper, MD, Thomas M. DeBerardino, MD, Michael J. Stuart, MD, Brett A. Lantz, MD, Kurt P. Spindler, MD, and MARS Group

Project: Predictors of Clinical Outcome Following Revision Anterior Cruciate Ligament Reconstruction


2019 Kappa Delta Elizabeth Winston Lanier Award

Researchers: Constance R. Chu, MD

Co-Authors: Ashley A. Williams, MS, Jennifer C. Erhar-Hledik, PhD, Matthew R. Titchenal, PhD, Yongxian Qian, PhD, and Thomas P. Andriacchi, PhD

Project: Visualizing Pre-Ostearthritis: Integrating MRI UTET2*with Mechanics and Biology to Combat Post-Traumatic Osteoarthritis


2019 OREF Clinical Research Award

Researchers: L. Andrew Koman, MD

Co-Authors: Beth Paterson Smith, PhD and Thomas L. Smith, PhD

Project: Musculoskeletal Uses of Botulinum Toxins: A 30 year Translational Journey at Wake Forest School of Medicine


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