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Chapter 08 Video 3: Pepetide Amphiphile into Nanofiber

December 22, 2016

Contributors: Wellington K Hsu, MD

The peptide amphiphile nanofiber is comprised of four components: a surface displayed epitope for protein binding, charged sides for solubility, a beta sheet domain encoding cylindrical shape, as well as a hydrophobic tail for aggregation. Through the interplay of individual molecules, in particular, the hydrophobic tail, a cylindrical micelle is formed where long fibers can be constructed, thereby increasing the surface area for cell binding and growth factor interaction. The epitope displayed on the outer shell can be designed to bind any number of growth factors that may optimize the microenvironment for tissue regeneration.

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