Chondroblastoma

Abstract

Chondroblastoma is a benign primary tumor of bone that is potentially locally aggressive, and represents approximately 1% of all biopsied and histologically analyzed benign bone tumors. Chondroblastoma is commonly diagnosed in patients between the ages of 5 and 25 years, and has a twofold greater predominance in males than in females. The radiographic appearance is usually that of a lytic lesion with a sclerotic rim of bone located in the epiphysis of a long bone. Histologically, chondroblastoma is characterized by a mixture of mononuclear cells and giant cells with a cartilaginous matrix. The mainstay of treatment of chondroblastoma is intralesional curettage. Complete removal of the lesion is a key factor in minimizing recurrence, but must be balanced against the risk of damage to articular cartilage or open physes. Local recurrence after curettage is observed in as many as one third of cases of chondroblastoma. Metastasis is rare but can occur, particularly to the lungs.

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