Obesity and Periprosthetic Joint Infection


With the rising prevalence of obesity in the general population, the role of obesity in predisposing to periprosthetic joint infection has come under scrutiny. Obesity adversely affects the immune system, creates an unfavorable local tissue environment at the surgical site, prolongs surgical time, impairs the delivery of antibiotics, and has been postulated as a risk factor for periprosthetic joint infection. This article examines the mechanisms through which obesity plays a role in periprosthetic joint infection, reviews the studies that have attempted to delineate this association, and explores options for prevention in the obese total joint arthroplasty patient.

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