Paget's Disease of Bone


Paget's disease of bone is a benign metabolic bone disease of the elderly. Diagnosis is typically based on characteristic features observed on radiographs. Measurement of serum alkaline phosphatase levels and bone scintigraphy have been shown to be sensitive for diagnosing Paget's disease of bone, especially in patients with a positive family history of the disease. Bisphosphonates are the mainstay of treatment and have been shown to heal radiographic lesions and restore normal histology. Paget's disease of bone can degenerate into a sarcoma, in which case it carries a poor prognosis. Although the exact etiology of Paget's disease of bone still remains unclear, future studies are directed to understanding the cell biology of the disease.

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